Svec F, Abadie J, Browne E S, Porter J R
Department of Medicine, Louisiana State University Medical School, New Orleans 70112, USA.
Appetite. 1995 Oct;25(2):143-54. doi: 10.1006/appe.1995.0051.
The effect of dehydroepiandrosterone (DHEA) on the macronutrient preference and total energy intake of lean and obese female Zucker rats was studied. Introduction of DHEA led to a rapid decrease in the consumption of fat, protein and total calories by the obese rat. DHEA treatment of the lean rat caused a change neither in its total energy consumption nor in its fat consumption, but did cause a distinct expression of preference for carbohydrate over protein. Both lean and obese animals gained weight rapidly during the steroid-free weeks and lost weight while consuming the DHEA-supplemented diet. The difference in weight changes seen with the obese rats between the DHEA-free and DHEA-supplemented periods could be accounted for by differences in caloric intake. Lean rats, however, did not change their total energy intake during DHEA-treatment periods; therefore, DHEA caused weight loss in the lean rat probably by altering energy metabolism. It is concluded that in the obese, young, female Zucker rat, DHEA alters macronutrient preference as well as caloric intake. In the lean rat, DHEA has a more subtle effect on relative macronutrient preference and not on total energy consumption.
研究了脱氢表雄酮（DHEA）对瘦型和肥胖型雌性 Zucker 大鼠的常量营养素偏好及总能量摄入的影响。给肥胖大鼠引入 DHEA 后，其脂肪、蛋白质和总热量的消耗量迅速下降。给瘦型大鼠使用 DHEA 治疗，既未改变其总能量消耗，也未改变其脂肪消耗，但确实导致了对碳水化合物的偏好明显高于蛋白质。在无类固醇的几周内，瘦型和肥胖型动物体重均迅速增加，而在食用补充了 DHEA 的饮食时体重减轻。肥胖大鼠在无 DHEA 和补充 DHEA 期间体重变化的差异可由热量摄入的差异来解释。然而，瘦型大鼠在 DHEA 治疗期间总能量摄入并未改变；因此，DHEA 可能通过改变能量代谢导致瘦型大鼠体重减轻。得出的结论是，在肥胖、年轻的雌性 Zucker 大鼠中，DHEA 会改变常量营养素偏好以及热量摄入。在瘦型大鼠中，DHEA 对相对常量营养素偏好的影响更为微妙，而对总能量消耗没有影响。
