Kida A, Endo S, Iida H, Yamada Y, Sakai F, Furusaka T, Ishiyama K
Department of Otorhinolaryngology, Nihon University Surugadai Hospital, Tokyo, Japan.
Auris Nasus Larynx. 1995;22(3):172-7. doi: 10.1016/s0385-8146(12)80055-1.
The subjects were 14 patients with squamous cell carcinoma or undifferentiated carcinoma of the nasal cavity treated at Nihon University Hospital between October 1984 and November 1991, who were followed for at least 3 years. The site of the tumor origin within the nasal cavity was the lateral wall in 8 patients, the nasal septum in three patients, and unknown in three patients. Histologically, there were 13 squamous cell carcinomas in (3 well differentiated, 7 moderately differentiated, and 3 poorly differentiated) and 1 undifferentiated carcinoma. Treatment was by a combination of radiotherapy, chemotherapy, and surgery in 8 cases, a combination of radiotherapy and surgery in 5 cases, and surgery alone in 1 case. The 3-year and 5-year Kaplan-Meier survival rates were 86 and 69%, respectively. A total of 6 patients suffered a recurrence, with local recurrence occurring in 4 patients and pulmonary metastasis in 2 patients. Tumor control was achieved in 3 of the 4 cases of local recurrence by reoperation, and by surgery in 1 of the 2 cases of pulmonary metastasis. The duration of the recurrence-free interval in the patients who developed local recurrences, 18 to 46 months after the completion of the initial course of therapy, was of considerable interest.
研究对象为1984年10月至1991年11月间在日本大学医院接受治疗的14例鼻腔鳞状细胞癌或未分化癌患者，这些患者均接受了至少3年的随访。肿瘤起源于鼻腔内的部位，8例位于侧壁，3例位于鼻中隔，3例不详。组织学上，有13例鳞状细胞癌（3例高分化、7例中分化、3例低分化）和1例未分化癌。治疗方法为：8例采用放疗、化疗和手术联合治疗，5例采用放疗和手术联合治疗，1例仅行手术治疗。3年和5年的Kaplan-Meier生存率分别为86%和69%。共有6例患者复发，4例为局部复发，2例发生肺转移。4例局部复发患者中有3例通过再次手术实现了肿瘤控制，2例肺转移患者中有1例通过手术实现了肿瘤控制。初始治疗疗程结束后18至46个月出现局部复发的患者，其无复发生存期的时长颇受关注。
