Nakamura T, Hoshi S, Nagasawa Y, Ueda S
Nippon Institute for Biological Science, Tokyo, Japan.
Avian Dis. 1995 Jul-Sep;39(3):507-13.
The effect of various routes of immunization on protection against challenge by virulent agents was examined in chickens. Chickens were immunized intratracheally, intranasally, per os, by crop gavage, and intramuscularly. Agents examined were killed Haemophilus paragallinarum, Mycoplasma gallisepticum, and infectious bursal disease virus. Results of immunization by intratracheal administration were equivalent to those produced by parenteral administration. All vaccines effectively induced production of serum antibodies against pathogens, and all immunized chickens were protected against infection by each pathogen.
在鸡身上研究了各种免疫途径对抵御强毒病原体攻击的保护效果。鸡通过气管内、鼻内、口服、嗉囊灌胃和肌肉内进行免疫。所检测的病原体有灭活的副鸡嗜血杆菌、鸡毒支原体和传染性法氏囊病病毒。气管内给药的免疫效果与肠胃外给药相当。所有疫苗均有效诱导了针对病原体的血清抗体产生，并且所有免疫鸡均受到保护，免受每种病原体的感染。
