Bermudez A J, Hopkins B A
Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Avian Dis. 1995 Jul-Sep;39(3):661-5.
An eighteen-month-old female rhea (Rhea americana) was presented dead for necropsy. The owner reported having observed blood in the droppings. Gross examination revealed a rhea in good body condition with a copious amount of frank blood in the cloaca. Large masses of matted fescue grass (Festuca spp.) distended the ventriculus and jejunum. No hemorrhage was evident in the digestive tract, which was otherwise void of ingesta. The kidneys were dark brown in color. Renal histopathology revealed a severe accumulation of eosinophilic pigment in the tubular epithelial cells of the proximal convoluted tubules, with tubular nephrosis and eosinophilic casts in the collecting tubules. It was concluded that the renal pigment was hemoglobin and not myoglobin, based on lack of evidence of muscle injury and the severe erythrophagocytosis evident in hepatic macrophages. The renal pigment also stained positive with the hemoglobin-specific Okajima stain. Hemoglobinuric nephrosis has not previously been reported in an avian species.
一只18个月大的雌性美洲鸵鸟（美洲鸵鸟属）被送来进行尸检，送来时已死亡。主人报告称观察到粪便中有血。大体检查发现这只美洲鸵鸟身体状况良好，泄殖腔内有大量鲜血。大量缠结的羊茅属植物（羊茅属）使嗉囊和空肠扩张。消化道未见明显出血，否则会有食糜。肾脏呈深褐色。肾脏组织病理学显示，近曲小管的肾小管上皮细胞中有严重的嗜酸性色素积聚，集合管中有肾小管肾病和嗜酸性管型。基于缺乏肌肉损伤的证据以及肝巨噬细胞中明显的严重红细胞吞噬作用，得出结论认为肾脏中的色素是血红蛋白而非肌红蛋白。肾脏色素用血红蛋白特异性冈岛染色也呈阳性。血红蛋白尿性肾病此前尚未在鸟类中报道过。
