小鼠γ-神经生长因子对合成肾素底物的特异性裂解作用。
Specific cleavage of synthetic renin substrate by mouse gamma-nerve growth factor.
作者信息
Uddin M, Beg O U
机构信息
Department of Anatomy and Cell Biology, Meharry Medical College, Nashville, Tennessee 37208, USA.
出版信息
J Protein Chem. 1995 Oct;14(7):621-5. doi: 10.1007/BF01886888.
PMID:8561858
Abstract
Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity. Since other mouse kallikreins do not cleave this bond, gamma-NGF may play a regulatory role in the generation of antiogensin-II.
摘要
本研究结果表明，属于激肽释放酶蛋白家族的小鼠γ-神经生长因子（γ-NGF）特异性切割合成肾素底物的苯丙氨酸-组氨酸键，并表现出类大鼠肾素的活性。由于其他小鼠激肽释放酶不切割此键，γ-NGF可能在血管紧张素-II的生成中发挥调节作用。
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