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小鼠γ-神经生长因子对合成肾素底物的特异性裂解作用。

Specific cleavage of synthetic renin substrate by mouse gamma-nerve growth factor.

作者信息

Uddin M, Beg O U

机构信息

Department of Anatomy and Cell Biology, Meharry Medical College, Nashville, Tennessee 37208, USA.

出版信息

J Protein Chem. 1995 Oct;14(7):621-5. doi: 10.1007/BF01886888.

DOI:10.1007/BF01886888
PMID:8561858
Abstract

Results of the present investigation indicate that mouse gamma-nerve growth factor (gamma-NGF), which belongs to the kallikrein family of proteins, specifically cleaves the Phe-His bond of a synthetic renin substrate and exhibits rat-tonin-like activity. Since other mouse kallikreins do not cleave this bond, gamma-NGF may play a regulatory role in the generation of antiogensin-II.

摘要

本研究结果表明，属于激肽释放酶蛋白家族的小鼠γ-神经生长因子（γ-NGF）特异性切割合成肾素底物的苯丙氨酸-组氨酸键，并表现出类大鼠肾素的活性。由于其他小鼠激肽释放酶不切割此键，γ-NGF可能在血管紧张素-II的生成中发挥调节作用。

相似文献

1
Specific cleavage of synthetic renin substrate by mouse gamma-nerve growth factor.小鼠γ-神经生长因子对合成肾素底物的特异性裂解作用。
J Protein Chem. 1995 Oct;14(7):621-5. doi: 10.1007/BF01886888.
2
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本文引用的文献

1
Isolation and characterization of a protein corresponding to mKlk-11 clone from male mouse submandibular gland.从雄性小鼠下颌下腺中分离并鉴定与mKlk-11克隆对应的蛋白质。
J Protein Chem. 1995 Jul;14(5):327-33. doi: 10.1007/BF01886789.
2
The molecular biology of the kallikrein-kinin system: I. General description, nomenclature and the mouse gene family.激肽释放酶-激肽系统的分子生物学：I. 概述、命名及小鼠基因家族
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3
Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor-binding protein, members of the kallikrein family.
神经生长因子-γ和表皮生长因子结合蛋白（激肽释放酶家族成员）对单链前体巨噬细胞刺激蛋白的蛋白水解激活作用。
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4
Aminopeptidase A is angiotensinase A- I. Quantitative histochemical studies in the kidney glomerulus.氨肽酶A即血管紧张素酶A-I。肾小球的定量组织化学研究。
Histochemistry. 1982;74(2):229-45. doi: 10.1007/BF00495833.
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Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence.从克隆的cDNA序列推导的人血管紧张素原前体的一级结构。
Biochemistry. 1984 Jul 31;23(16):3603-9. doi: 10.1021/bi00311a006.
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Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous.小鼠神经生长因子α和γ亚基的基因是相邻的。
EMBO J. 1985 Jan;4(1):133-8. doi: 10.1002/j.1460-2075.1985.tb02327.x.
7
Angiotensin II generated by a human renal carboxypeptidase.由人肾羧肽酶产生的血管紧张素II。
Biochem Biophys Res Commun. 1986 Jul 31;138(2):573-9. doi: 10.1016/s0006-291x(86)80535-6.
8
Processing of the native nerve growth factor precursor to form biologically active nerve growth factor.
J Biol Chem. 1988 May 15;263(14):6810-5.
9
Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins.小鼠腺体激肽释放酶基因：编码表皮生长因子结合蛋白的基因的鉴定与表征
Biochemistry. 1987 Oct 20;26(21):6750-6. doi: 10.1021/bi00395a026.
10
Sequence and expression of mouse gamma-renin.小鼠γ-肾素的序列与表达
J Biol Chem. 1988 Jun 25;263(18):8565-8.