二磷酸腺苷对人脐血管的作用：新型血小板衍生的血管收缩剂。
Effect of diadenosine phosphates on human umbilical vessels: novel platelet-derived vasoconstrictors.
作者信息
Davies G, MacAllister R J, Bogle R G, Vallance P
机构信息
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, UK.
出版信息
Br J Clin Pharmacol. 1995 Aug;40(2):170-2. doi: 10.1111/j.1365-2125.1995.tb05773.x.
The responses of human isolated umbilical artery to the novel platelet-derived mediators, diadenosine phosphates, P1,P5-di(adenosine-5')pentaphosphate (AP5A) and P1,P6-di(adenosine-5')hexaphosphate (AP6A) were studied in vitro. AP5A (1 nM-300 microM; n = 7) and AP6A (1 nM-30 microM; n = 5) produced transient concentration-dependent contractions. Responses to AP5A were unaffected by co-incubation with indomethacin (10 microM; n = 4), NGmonomethyl-L-arginine (L-NMMA; 300 microM; n = 4) and theophylline (1 microM; n = 5). These results demonstrate that diadenosine phosphates have constrictor effects on human blood vessels in vitro and are consistent with a role for these platelet-derived mediators in the regulation of blood vessel tone.
体外研究了人离体脐动脉对新型血小板衍生介质二磷酸腺苷、P1,P5 - 二（腺苷 - 5'）五磷酸（AP5A）和P1,P6 - 二（腺苷 - 5'）六磷酸（AP6A）的反应。AP5A（1 nM - 300 microM；n = 7）和AP6A（1 nM - 30 microM；n = 5）产生短暂的浓度依赖性收缩。与吲哚美辛（10 microM；n = 4）、NG - 单甲基 - L - 精氨酸（L - NMMA；300 microM；n = 4）和茶碱（1 microM；n = 5）共同孵育时，对AP5A的反应不受影响。这些结果表明，二磷酸腺苷在体外对人体血管具有收缩作用，并且与这些血小板衍生介质在血管张力调节中的作用一致。
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