Guillaud M, Doudkine A, Garner D, MacAulay C, Palcic B
Cancer Imaging Department, British Columbia Cancer Agency, Vancouver, Canada.
Anal Cell Pathol. 1995 Oct;9(3):191-204.
For almost ten years. Malignancy Associated Changes have been consistently found by means of high resolution image analysis of apparently normal uterine cervix cells. The study was performed on normal intermediate cells randomly selected from 1850 cervical smear slides classified as negative, mild dysplasia, moderate dysplasia and severe dysplasia. Size and texture features, performed by the Cyto-Savant software, have shown significant monotonic changes with the grade of dysplasia. These findings indicate that the intensity of Malignancy Associated Changes are directly related to the severity of the adjacent lesions.
近十年来，通过对看似正常的子宫颈细胞进行高分辨率图像分析，一直发现与恶性肿瘤相关的变化。该研究对从1850张宫颈涂片玻片（分类为阴性、轻度发育异常、中度发育异常和重度发育异常）中随机选取的正常中间细胞进行。由Cyto-Savant软件进行的大小和纹理特征分析显示，随着发育异常程度的增加，出现了显著的单调变化。这些发现表明，与恶性肿瘤相关的变化强度与相邻病变的严重程度直接相关。
