Macklon N S, Greer I A, Reid A W, Walker I D
University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, UK.
Blood Coagul Fibrinolysis. 1995 Oct;6(7):672-5. doi: 10.1097/00001721-199510000-00008.
Pregnancy limits the therapeutic options for managing thrombocytopenia which occurs in 5% of patients on heparin. We describe a case of extensive thromboembolism associated with antithrombin (AT) deficiency complicated by thrombocytopenia which resolved when low-molecular-weight heparin was instituted. A primigravid woman presented at 11 weeks gestation with bilateral femoral occlusive thrombi extending above the renal veins. Investigations revealed AT deficiency, thrombocytopenia and renal infarction. After low-molecular-weight heparin was substituted for unfractionated heparin, the thrombocytopenia resolved and although the pregnancy was lost, the patient made a full recovery.
妊娠限制了肝素治疗的血小板减少症（发生率为5%）的治疗选择。我们描述了1例抗凝血酶（AT）缺乏合并血小板减少症并发广泛血栓栓塞的病例，该病例在使用低分子肝素后病情得到缓解。一名初产妇在妊娠11周时出现双侧股静脉闭塞性血栓，血栓延伸至肾静脉上方。检查发现抗凝血酶缺乏、血小板减少症和肾梗死。在用低分子肝素替代普通肝素后，血小板减少症得到缓解，尽管妊娠失败，但患者完全康复。
