Steffenburg U, Hagberg G, Kyllerman M
Department of Pediatrics, University of Göteborg, Ostra Hospital, Sweden.
Acta Paediatr. 1995 Oct;84(10):1153-9. doi: 10.1111/j.1651-2227.1995.tb13516.x.
A population-based study of active epilepsy in mentally retarded children identified 98 children, 6-13 years old. A biopathological origin was established in 66% of mildly and 92% of severely retarded children: a prenatal etiology was considered in 51% and 57%, a perinatal in 9% and 19%, a postnatal in 6% and 16% and an untraceable etiology in 34% and 8%, respectively. Severe mental retardation was more frequent in the peri- and postnatal groups (80% and 83%) than in the prenatal and untraceable groups (67% and 29%). Thirty-four pre- and perinatal optimal items were defined. Children with a prenatal etiology did not differ from controls in any of the periods. Children with a perinatal etiology had, compared with controls, higher proportions of non-optimal items successively increasing through the pre- and perinatal periods showing the accumulation of negative events.
一项针对智障儿童活动性癫痫的基于人群的研究，确定了98名6至13岁的儿童。在轻度智障儿童中，66%以及重度智障儿童中92%确定了生物病理学起源：分别有51%和57%认为是产前病因，9%和19%是围产期病因，6%和16%是产后病因，34%和8%是无法追查的病因。围产期和产后组中重度智力迟钝更为常见（分别为80%和83%），高于产前组和无法追查病因组（分别为67%和29%）。定义了34项产前和围产期最佳指标。产前病因的儿童在任何时期与对照组均无差异。与对照组相比，围产期病因的儿童在产前和围产期非最佳指标的比例逐渐增加，显示出负面事件的累积。
