Iaremenko B R, Keerig Iu Iu
Biull Eksp Biol Med. 1977 Feb;83(2):143-5.
In experiments reproducing traumatic shock according to Cannon on 35 dogs it was shown that metabolic acidosis developed in shock against the background of sharply elevated oxgen consumption at the very beginning of injury, when the arterial pressure exceeds considerably the inital level. In traumatic shock the brain is under the most favourable conditions of gas exchange and the skeletal musculature of the extremities--under the worst ones. It was concluded that in severe trauma, despite the strain of respiratory and cardiovascular system function the tissues of the brain and the skeletal muscles failed to obtain an adequate O2 quantity because of their sharply increases needs in oxygen, as well as of hemodynamic disturbances.
在按照坎农的方法对35只狗进行创伤性休克复制的实验中发现,在损伤刚开始时,当动脉压大幅超过初始水平,且氧消耗急剧增加的背景下,休克时会发生代谢性酸中毒。在创伤性休克中,大脑处于气体交换最有利的条件下,而四肢的骨骼肌则处于最不利的条件下。得出的结论是,在严重创伤中,尽管呼吸和心血管系统功能受到压力,但由于大脑和骨骼肌对氧气的需求急剧增加以及血流动力学紊乱,它们的组织未能获得足够的氧气量。