Sato M, Murao K, Matsubara S, Niimi M, Chihara K, Takahara J
First Department of Internal Medicine, Kagawa Medical School, Miki-Cho, Japan.
J Neuroendocrinol. 1995 Oct;7(10):801-5. doi: 10.1111/j.1365-2826.1995.tb00717.x.
The mechanisms involved in 2-deoxy-D-glucose (2-DG)-induced growth hormone (GH) suppression in the rat were examined. Conscious male rats were given 2-DG by intracerebroventricular (icv) injection and the pulsatile GH secretion was monitored for 6 h. The single icv injection of 2-DG (8 mg/rat) eliminated pulsatile GH secretion in conscious rats. Pretreatment with somatostatin (SS) antiserum completely restored the suppressed GH secretion in the 2-DG treated rats. Hypothalamic GH-releasing hormone (GRH) and SS mRNA levels were not altered by single and multiple icv injections of 2-DG. These findings suggest that 2-DG-induced GH suppression is primarily due to hypersecretion of SS without a significant change at the transcription level in the rat.
研究了2-脱氧-D-葡萄糖（2-DG）诱导大鼠生长激素（GH）分泌受抑制的机制。给清醒雄性大鼠脑室内（icv）注射2-DG，并监测6小时的GH脉冲式分泌。单次icv注射2-DG（8mg/只大鼠）可消除清醒大鼠的GH脉冲式分泌。用生长抑素（SS）抗血清预处理可完全恢复2-DG处理大鼠中受抑制的GH分泌。单次和多次icv注射2-DG均未改变下丘脑生长激素释放激素（GRH）和SS的mRNA水平。这些发现表明，2-DG诱导的GH分泌受抑制主要是由于SS分泌过多，而大鼠转录水平无明显变化。
