Roger M, Galeano C
Brain Res. 1977 Apr 1;124(3):449-56. doi: 10.1016/0006-8993(77)90946-5.
The activity of the crayfish caudal photoreceptor (Ph) was studied during the application of a classical conditioning paradigm. This cell is a primary photoreceptor and, at the same time, a secondary neuron in the mechanoreceptive pathway. The electrical stimulation of afferent mechanoreceptor fibers, the analog of the conditioned stimulus (ACS), produced a slight increase in the Ph firing rate. The photic stimulation, the analog of the unconditioned stimulus (AUS), produced a marked increase in the Ph firing rate. After ACS-AUS pairing, a decrease in the Ph firing rate appeared during the ACS-AUS interval, and it was considered the analog of the conditioned response (ACR). This inhibitory response gradually vanished during extinction. The application of ACS or AUS series alone did not produce a response similar to the ACR, this excluding sensitization as a possible cuase. The ACR meets several conventional criteria accepted in learning, supporting the idea that the crayfish caudal photoreceptor is part of a small neuronal network able to learn in the isolated nerve cord preparation.
在应用经典条件反射范式的过程中，对小龙虾尾端光感受器（Ph）的活动进行了研究。该细胞是初级光感受器，同时也是机械感受通路中的次级神经元。对传入机械感受器纤维进行电刺激，即条件刺激类似物（ACS），会使Ph的放电频率略有增加。光刺激，即非条件刺激类似物（AUS），会使Ph的放电频率显著增加。在ACS-AUS配对后，在ACS-AUS间隔期间Ph的放电频率出现下降，这被认为是条件反应（ACR）的类似物。这种抑制性反应在消退过程中逐渐消失。单独应用ACS或AUS系列不会产生类似于ACR的反应，这排除了敏化作为可能原因的可能性。ACR符合学习中接受的几个传统标准，支持了小龙虾尾端光感受器是能够在离体神经索标本中学习的小神经元网络的一部分这一观点。
