Mason P, Harrison G, Glazebrook C, Medley I, Dalkin T, Croudace T
Department of Psychiatry, University Hospital, Nottingham.
Br J Psychiatry. 1995 Nov;167(5):596-603. doi: 10.1192/bjp.167.5.596.
This paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia.
In a 13-year follow-up study of a cohort identified in Nottingham in 1978-80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments.
Four of the original 67 patients with ICD-9 schizophrenia were lost to follow-up and five were dead: 52% were without psychotic symptoms in the last two years of follow-up, 52% were without negative symptoms and 55% showed good/fair social functioning. However, only 17% were alive at follow-up, without symptoms and disability, and receiving no treatment.
The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.
本文描述了一组符合流行病学定义且具有代表性的精神分裂症患者首次发病时的13年随访结果。
在一项对1978 - 1980年于诺丁汉确定的队列进行的13年随访研究中，使用标准化工具评估结果（症状、残疾、居住情况和治疗情况）。
最初的67例符合国际疾病分类第九版（ICD - 9）精神分裂症诊断标准的患者中，4例失访，5例死亡：在随访的最后两年中，52%的患者无精神病症状，52%无阴性症状，55%社会功能良好/尚可。然而，随访时仅17%的患者存活，无症状、无残疾且未接受治疗。
所报告的研究结果与其他精神分裂症长期随访研究以及5年随访研究的结果相似。支持了克雷佩林对精神分裂症诊断纵向影响的强调，但可能过于悲观。
