Metzger M M, Riccio D C
Department of Psychology, Kent State University, OH 44242, USA.
Neurobiol Learn Mem. 1995 Nov;64(3):245-56. doi: 10.1006/nlme.1995.0007.
A nonbarbiturate anesthetic consisting of ketamine HCl (Ketaset) and xlyazine (Rompun) was administered to assess the effects of anesthesia on hypothermia-induced retrograde amnesia in Long Evans hooded and Sprague-Dawley albino rats. Results from Experiment 1a indicate that this anesthetic does not attenuate retrograde amnesia, and the findings from Experiment 1b suggest that awakening from Ketaset/Rompun anesthesia at normal body temperature (following administration of deep body cooling) does not attenuate the resulting hypothermia-induced retrograde amnesia. Experiment 2 demonstrated that various delays between training and hypothermia resulted in a temporal gradient that was the same for animals cooled while either conscious or under anesthesia. The results of Experiment 3 showed that rats made amnesic while under anesthesia did not recover the target memory if given a recooling treatment, but rats that were made amnesic while conscious did recover the memory with the same reminder treatment. These findings indicate that the conscious processing of stimuli associated with hypothermia treatment is not necessary in inducing hypothermia-induced retrograde amnesia, but that conscious processing is an important factor if the amnesia is to be recovered with a recooling treatment.
将由盐酸氯胺酮（凯他敏）和甲苯噻嗪（隆朋）组成的一种非巴比妥类麻醉剂用于评估麻醉对长爪沙鼠和斯普拉格-道利白化大鼠低温诱导的逆行性遗忘的影响。实验1a的结果表明，这种麻醉剂不会减轻逆行性遗忘，实验1b的结果表明，在正常体温下（给予深度体冷却后）从凯他敏/隆朋麻醉中苏醒不会减轻由此产生的低温诱导的逆行性遗忘。实验2表明，训练与低温之间的各种延迟导致了一种时间梯度，对于清醒或麻醉状态下冷却的动物来说是相同的。实验3的结果表明，麻醉状态下产生遗忘的大鼠如果接受再次冷却处理，不会恢复目标记忆，但清醒状态下产生遗忘的大鼠在接受相同的提示处理后会恢复记忆。这些发现表明，在诱导低温诱导的逆行性遗忘时，与低温处理相关的刺激的有意识加工并非必要，但如果要通过再次冷却处理恢复遗忘，有意识加工是一个重要因素。
