Ionophoretic properties of the non-sulfonylurea hypoglycemic agents A-4166 and KAD-1229.

The non-sulphonylurea hypoglycaemic agents A-4166 and KAD-1229 were both found to cause 45Ca or 22Na translocation from an aqueous medium into an organic immiscible phase. This ionophoretic effect was more marked with A-4166 than KAD-1229, in mirror image of their insulinotropic potency. Such a dissociated behaviour argues against the view that the ionophoretic properties of these agents represent a major determinant of their insulinotropic action.