Rascati K
College of Pharmacy, Division of Pharmacy Administration, University of Texas at Austin, USA.
Clin Ther. 1995 Jul-Aug;17(4):786-90. doi: 10.1016/0149-2918(95)80055-7.
Side effects of some antidepressants include anxiety and insomnia. A retrospective drug utilization review was conducted to determine the amount of concurrent use of an antidepressant with medication that may counteract these side effects. Texas Medicaid claims data for 1993 included more than 30,000 patients receiving a specific serotonin reuptake inhibitor (SSRI) or clomipramine. A total of 35.0% of these patients were also taking a medication that could be used to relieve anxiety or induce sleep, and 15.2% of the total were receiving once-daily dosing of the latter type of medication. Concomitant use of SSRIs or clomipramine with trazodone occurred in 7.7% of the patients.
一些抗抑郁药的副作用包括焦虑和失眠。开展了一项回顾性药物利用审查，以确定抗抑郁药与可能抵消这些副作用的药物同时使用的情况。1993年得克萨斯州医疗补助索赔数据涵盖了3万多名正在服用特定血清素再摄取抑制剂（SSRI）或氯米帕明的患者。这些患者中共有35.0%还在服用可用于缓解焦虑或诱导睡眠的药物，且总计15.2%的患者接受了后者这类药物的每日一次给药。7.7%的患者同时使用了SSRI或氯米帕明与曲唑酮。
