Kossovsky N, Conway D, Kossowsky R, Petrovich D
Department of Pathology, UCLA School of Medicine, USA.
Curr Top Microbiol Immunol. 1996;210:327-36. doi: 10.1007/978-3-642-85226-8_35.
The frequency of novel autoreactive antibodies to silicone surface associated antigens (anti-SSAA(x)) was measured in healthy control patients, symptomatic patients with breast implants, asymptomatic patients with breast implants, and control patients with classical rheumatological diseases. The frequencies of elevated anti-SSAA(x) antibodies in 310 symptomatic breast implant patients were 17.4% anti-SSAA(fn), 12.9% anti-SSAA(col1), and 7.4% anti-SSAA(col3) and 7.1% anti-SSAA(fbgn) [Normal (n = 173) = 0.6% for all four tests] (p < .005). In 11 asymptomatic breast implant patients, the frequencies of elevated values for the same anti-SSAA's were 0%, 9%, 0%, and 0% respectively, while in 50 patients with rheumatoid arthritis, the frequencies were 4%, 0%, 6% and 2% respectively. The anti-SSAA(x) profile for symptomatic patients with breast implants was different than the profile for control healthy patients (p < .005 on all eight tests) but differed significantly by two measures, anti-SSAA(fbgn) and anti-SSAA(col3), from the profile for the 19 patients with systemic lupus erythematosus. We conclude that anti-SSAA(x) antibodies levels in symptomatic patients with breast implants are elevated, that the antibodies are associated with symptoms, and that they differ both qualitatively and quantitatively from healthy controls, asymptomatic patients with breast implants, and symptomatic patients with classical rheumatological diseases.
在健康对照患者、有症状的乳房植入患者、无症状的乳房植入患者以及患有经典风湿性疾病的对照患者中，测量了针对硅胶表面相关抗原的新型自身反应性抗体（抗SSAA(x)）的频率。310名有症状的乳房植入患者中，抗SSAA(fn)抗体升高的频率为17.4%，抗SSAA(col1)为12.9%，抗SSAA(col3)为7.4%，抗SSAA(fbgn)为7.1%[所有四项检测中，正常组（n = 173）均为0.6%]（p < 0.005）。在11名无症状的乳房植入患者中，相同抗SSAA抗体升高的频率分别为0%、9%、0%和0%，而在50名类风湿性关节炎患者中，频率分别为4%、0%、6%和2%。有症状的乳房植入患者的抗SSAA(x)谱与健康对照患者不同（八项检测均p < 0.005），但与19名系统性红斑狼疮患者的谱在抗SSAA(fbgn)和抗SSAA(col3)这两项指标上有显著差异。我们得出结论，有症状的乳房植入患者中抗SSAA(x)抗体水平升高，这些抗体与症状相关，并且它们在质量和数量上均与健康对照、无症状的乳房植入患者以及有症状的经典风湿性疾病患者不同。
