Aguirre N, Galbete J L, Lasheras B, Del Río J
Department of Pharmacology, University of Navarra, Pamplona, Spain.
Eur J Pharmacol. 1995 Jul 25;281(1):101-5. doi: 10.1016/0014-2999(95)00303-3.
The present study examined the short- and long-term effects of single and repeated administration of 3,4-methylenedioxy-methamphetamine (MDMA, 'ecstasy') on somatodendritic and postsynaptic 5-HT1A receptors of the rat brain. [3H]8-Hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) was used to label 5-HT1A receptors in the brain stem region containing the dorsal raphe nucleus and in the frontal cortex. As expected, both schedules of treatment reduced the serotonin (5-hydroxytryptamine, 5-HT) content and [3H]paroxetine binding in the frontal cortex but not in the brain stem. Multiple but not single MDMA administration significantly reduced 5-HT1A receptor density in the selected brain stem region. In the frontal cortex, both MDMA treatments increased or tended to increase 5-HT1A receptor number, the effect being more marked after repeated drug administration.
本研究考察了单次及重复给予3,4-亚甲基二氧甲基苯丙胺（MDMA，“摇头丸”）对大鼠脑内树突体和突触后5-羟色胺1A（5-HT1A）受体的短期和长期影响。使用[3H]8-羟基-2-（二正丙基氨基）四氢萘（[3H]8-OH-DPAT）标记包含中缝背核的脑干区域及额叶皮质中的5-HT1A受体。正如预期的那样，两种给药方案均降低了额叶皮质中5-羟色胺（5-羟色胺，5-HT）含量及[3H]帕罗西汀结合，但对脑干无此影响。多次而非单次给予MDMA显著降低了所选脑干区域的5-HT1A受体密度。在额叶皮质中，两种MDMA给药方案均增加或倾向于增加5-HT1A受体数量，重复给药后该效应更为明显。
