Fernández-Guasti A, Picazo O
Departamento de Farmacología y Toxicología, CINVESTAV, México D.F., Mexico.
Eur J Pharmacol. 1995 Jul 25;281(1):113-5. doi: 10.1016/0014-2999(95)00311-8.
In the burying behaviour test allopregnanolone (0.5 mg/rat) reduced the cumulative time of burying, interpreted as a reduction in anxiety. The selective benzodiazepine antagonist, flumazenil (5 and 10 mg/kg), did not affect the burying behaviour when administered alone but effectively prevented the reduction produced by allopregnanolone. No scheme modified the ambulatory behaviour, thus suggesting that the effect of these treatments was selective on experimental anxiety. These results indicate that the anxiolytic actions of neurosteroids are most likely mediated via the stimulation of GABAA receptors. Data are discussed on the basis of such relationships.
在掩埋行为测试中，别孕烯醇酮（0.5毫克/只大鼠）减少了累积掩埋时间，这被解释为焦虑减轻。选择性苯二氮䓬拮抗剂氟马西尼（5和10毫克/千克）单独给药时不影响掩埋行为，但能有效阻止别孕烯醇酮产生的减少作用。没有哪种方案改变了自主活动行为，因此表明这些处理的效果对实验性焦虑具有选择性。这些结果表明，神经甾体的抗焦虑作用很可能是通过刺激GABAA受体介导的。基于这些关系对数据进行了讨论。
