Fundytus M E, Schiller P W, Shapiro M, Weltrowska G, Coderre T J
Pain Mechanisms Laboratory, Clinical Research Institute of Montreal, Quebec, Canada.
Eur J Pharmacol. 1995 Nov 3;286(1):105-8. doi: 10.1016/0014-2999(95)00554-x.
We examined the effects of i.c.v. treatment with naltrindole, and the two highly selective peptide delta-opioid receptor antagonists H-Tyr-Tic-Phe-Phe-OH (TIPP) and H-Tyr-Tic psi [CH2-NH]-Phe-Phe- OH (TIPP[psi]), on the development of morphine tolerance and dependence. Each treatment significantly decreased naloxone-precipitated withdrawal, with TIPP[psi] reducing the most symptoms. TIPP[psi], but neither naltrindole nor TIPP, attenuated the development of analgesic tolerance in the tail-flick test. These results suggest that delta-opioid receptors are critically involved in the development of morphine tolerance and dependence.
我们研究了脑室内注射纳曲吲哚以及两种高选择性肽类δ-阿片受体拮抗剂H-Tyr-Tic-Phe-Phe-OH（TIPP）和H-Tyr-Tic psi [CH2-NH]-Phe-Phe-OH（TIPP[psi]）对吗啡耐受性和依赖性形成的影响。每种治疗均显著降低了纳洛酮诱发的戒断反应，其中TIPP[psi]减轻的症状最多。TIPP[psi]可减弱甩尾试验中镇痛耐受性的形成，但纳曲吲哚和TIPP均无此作用。这些结果表明，δ-阿片受体在吗啡耐受性和依赖性的形成中起关键作用。
