精液中的雄激素：男性生殖道表面上皮的标志物。

Zalata A, Hafez T, Verdonck L, Vermeulen L, Comhaire F

Mansoura University, Egypt.

Int J Androl. 1995 Oct;18(5):271-7.

Androgens in seminal plasma have been investigated in relation to other markers of the male reproductive system. Testosterone and dihydrotestosterone (DHT) were measured by radioimmunoassay after paper chromatography in 104 semen samples. Concentrations of testosterone and DHT were significantly lower in samples from patients with abnormal sperm characteristics than in men with normozoospermia. Both testosterone and DHT were correlated significantly with sperm concentration (r = 0.40, p < 0.001; r = 0.41, p < 0.001, respectively), motile sperm concentration (r = 0.35, p < 0.01; r = 0.35, p < 0.01) and ATP concentration (r = 0.59, p < 0.001; r = 0.45, p < 0.001). In addition, the total amounts of testosterone and DHT were correlated with total activity of alpha-glucosidase (r = 0.49, p < 0.001; r = 0.58, p < 0.01), and gamma-glutamyltransferase (r = 0.49, p < 0.001; r = 0.48, p < 0.001) in seminal plasma. Transferrin (Tf) concentration in seminal plasma was significantly lower in samples without spermatozoa, and total Tf content was lower in oligozoospermic samples (p < 0.05). Testosterone and DHT were correlated positively with Tf levels in seminal plasma (r = 0.48, p < 0.0001; r = 0.78, p < 0.0001 respectively). Testosterone, DHT and Tf in seminal plasma were higher in the first than in the second fraction of split ejaculates, and DHT, but not testosterone, increased significantly in each of six patients treated with tamoxifen. Testosterone, DHT, and Tf in seminal plasma were not correlated with serum concentrations of LH, FSH, testosterone or prolactin, but the DHT : T ratio in seminal plasma was correlated with serum LH (r = 0.36, p < 0.05). It is concluded that the concentration of androgens in seminal plasma is related predominantly to the activity of the seminiferous epithelium and, to a lesser extent, to the function of the accessory sex glands.

人们对精浆中的雄激素与男性生殖系统的其他标志物进行了相关性研究。采用放射免疫分析法，在纸色谱分离后测定了104份精液样本中的睾酮和双氢睾酮（DHT）。精子特征异常患者样本中的睾酮和DHT浓度显著低于正常精子症男性。睾酮和DHT均与精子浓度（分别为r = 0.40，p < 0.001；r = 0.41，p < 0.001）、活动精子浓度（r = 0.35，p < 0.01；r = 0.35，p < 0.01）和ATP浓度（r = 0.59，p < 0.001；r = 0.45，p < 0.001）显著相关。此外，睾酮和DHT的总量与精浆中α - 葡萄糖苷酶的总活性（r = 0.49，p < 0.001；r = 0.58，p < 0.01）以及γ - 谷氨酰转移酶（r = 0.49，p < 0.001；r = 0.48，p < 0.001）相关。无精子样本中精浆转铁蛋白（Tf）浓度显著降低，少精子症样本中Tf总含量降低（p < 0.05）。睾酮和DHT与精浆中Tf水平呈正相关（分别为r = 0.48，p < 0.0001；r = 0.78，p < 0.0001）。射精分段的第一部分精浆中的睾酮、DHT和Tf高于第二部分，在接受他莫昔芬治疗的6名患者中，DHT（而非睾酮）在每例患者中均显著增加。精浆中的睾酮、DHT和Tf与血清促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮或催乳素浓度无关，但精浆中DHT : T比值与血清LH相关（r = 0.36，p < 0.05）。研究得出结论，精浆中雄激素的浓度主要与生精上皮的活性有关，并在较小程度上与附属性腺的功能有关。