Wisanto A, Magnus M, Bonduelle M, Liu J, Camus M, Tournaye H, Liebaers I, Van Steirteghem A C, Devroey P
Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel, Belgium).
Hum Reprod. 1995 Oct;10(10):2713-8. doi: 10.1093/oxfordjournals.humrep.a135773.
An evaluation of the outcome of pregnancies resulting from intracytoplasmic sperm injection for severe male factor infertility was conducted by analysing the data obtained from the patients and/or their obstetrician/gynaecologist on standardized questionnaires. The data from 424 pregnancies between April 1991 and September 1994 were analysed. Early pregnancy loss before 16 weeks occurred in 99 cases (23.3%), including 48 clinical abortions (11.3%), 47 subclinical pregnancies (11.1%) and four ectopic pregnancies (0.9%). Vanishing twins and triplets, which could be regarded as early embryonic wastage, were found in 36 cases (8.5%). One pregnancy was interrupted at week 15 of gestation because of anhydramnios, and four pregnancies (0.9%) ended in spontaneous late abortions before 26 weeks. A total of 320 pregnancies (75.5%) resulted in the birth of at least one child; 222 of these (69.3%) were singletons, 93 were twins (29.1%) and five were triplets (1.6%). The problems of prematurity and low birthweight were especially related to the multiplicity of pregnancies. Furthermore, from among the total of 423 babies born, we have observed three cases of stillbirth and five cases of neonatal mortality. The perinatal mortality rate was therefore 18.9 per 1000 births. The results of this study show that the obstetric outcome of these pregnancies was similar to that obtained after conventional in-vitro fertilization and other assisted reproduction techniques.
通过分析患者和/或其妇产科医生在标准化问卷上提供的数据，对严重男性因素不育患者卵胞浆内单精子注射后的妊娠结局进行了评估。分析了1991年4月至1994年9月期间424例妊娠的数据。16周前的早期妊娠丢失发生在99例（23.3%），包括48例临床流产（11.3%）、47例亚临床妊娠（11.1%）和4例异位妊娠（0.9%）。在36例（8.5%）中发现了消失的双胎和三胎，可视为早期胚胎丢失。1例妊娠在妊娠第15周因羊水过少而终止，4例妊娠（0.9%）在26周前自然发生晚期流产。共有320例妊娠（75.5%）至少分娩1个孩子；其中222例（69.3%）为单胎，93例为双胎（29.1%），5例为三胎（1.6%）。早产和低出生体重问题尤其与多胎妊娠有关。此外，在总共出生的423名婴儿中，我们观察到3例死产和5例新生儿死亡。因此围产儿死亡率为每1000例出生18.9例。本研究结果表明，这些妊娠的产科结局与传统体外受精和其他辅助生殖技术后的结局相似。
