Ugen K E
Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, USA.
J Fla Med Assoc. 1995 Dec;82(12):825-6.
With an increase in the number of women of childbearing age being infected with HIV-1, the incidence of pediatric AIDS is rising precipitously. Therefore, it is necessary to identify the risks and the potential preventive methods that may be effective in decreasing the transmission from mother to child, i.e., vertical transmission. Administration of zidovudine has been demonstrated to significantly lower the rate of vertical transmission. Passive and active vaccination may also be useful in diminishing the transmission rate. Likewise, methods which provide a rapid and predictive measurement of the likelihood of vertical transmission, such as qualitative and quantitative differences in anti-HIV-1 maternal antibodies between transmitters and nontransmitters, have potential clinical utility.
随着育龄期感染人类免疫缺陷病毒1型（HIV-1）的女性数量增加，儿童艾滋病的发病率急剧上升。因此，有必要确定可能有效降低母婴传播（即垂直传播）的风险和潜在预防方法。已证明服用齐多夫定可显著降低垂直传播率。被动和主动疫苗接种也可能有助于降低传播率。同样，能够快速预测垂直传播可能性的方法，如传播者与非传播者之间抗HIV-1母体抗体的定性和定量差异，具有潜在的临床应用价值。
