Kato M, Mizuguchi M, Takashima S
Department of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
J Neurosci Res. 1995 Nov 1;42(4):486-92. doi: 10.1002/jnr.490420407.
We investigated the immunohistochemical localization of epidermal growth factor (EGF) in the developing human brain from 6 weeks of gestation to 3 months postpartum. EGF-like immunoreactivity varied in its localization and intensity according to the stage of development. At 10 - 20 weeks of gestation, EGF-like immunoreactivity appeared in proliferating and migrating cells in the cerebrum, disappeared thereafter, and appeared again in cortical neurons after 27 weeks of gestation. Astrocytes also showed EGF-like immunoreactivity from 27 weeks of gestation. These results suggest developmental regulation of EGF expression in the human brain, suggesting its physiological role in both neuronal and glial cells.
我们研究了表皮生长因子（EGF）在妊娠6周的发育中的人类大脑至产后3个月的免疫组织化学定位。EGF样免疫反应性的定位和强度根据发育阶段而变化。在妊娠10 - 20周时，EGF样免疫反应性出现在大脑中的增殖和迁移细胞中，此后消失，并在妊娠27周后再次出现在皮质神经元中。星形胶质细胞从妊娠27周开始也显示出EGF样免疫反应性。这些结果提示人脑中EGF表达的发育调控，表明其在神经元和神经胶质细胞中的生理作用。
