Perez-Reyes E, Schneider T
Department of Physiology, Loyola University Medical Center, Maywood, Illinois, USA.
Kidney Int. 1995 Oct;48(4):1111-24. doi: 10.1038/ki.1995.395.
Pharmacological and electrophysiological studies have established that there are multiple types of voltage-gated Ca2+ channels. Molecular biology has uncovered an even greater number of channel molecules. Thus, the molecular diversity of Ca2+ channels has its basis in the expression of many alpha 1 and beta genes, and also in the splice variants produced from these genes. This ability to mix and match subunits provides the cell with yet another mechanism to control the influx of calcium. Future studies will describe new subunits, the subunit composition of each type of channel, and the cloning of new Ca2+ channel types.
药理学和电生理学研究已证实存在多种类型的电压门控Ca2+通道。分子生物学揭示了更多数量的通道分子。因此，Ca2+通道的分子多样性基于许多α1和β基因的表达，以及这些基因产生的剪接变体。这种亚基混合和匹配的能力为细胞提供了另一种控制钙内流的机制。未来的研究将描述新的亚基、每种通道类型的亚基组成以及新的Ca2+通道类型的克隆。
