Kuljić T, Pavlović S, Kozarević N, Bosnjak-Petrović V, Filipović M, Bosnjaković V
Institute of nuclear medicine, University Clinical Centre, Belgrade.
Med Pregl. 1993;46 Suppl 1:29-31.
Measuring of the rate of radioactivity decrease of inhaled 99mTc-DTPA aerosol may detect disorders of alveocapillary membrane integrity. The study included 21 patients (11 non-smokers and 10 smokers) suffering from different pulmonary diseases (pulmonary embolism - PE; chronic obstructive pulmonary disease - COPD; pneumonia - PN; occupational diseases - OD) in order to detect disorders of pulmonary epithelial permeability (PEP) and 2 healthy individuals (non-smokers) with normal findings (NF). DTPA was labelled using the standard procedure with 1480 MBq 99mTc in 1 ml of physiologic saline. Patients with nasal obstruction inhaled aerosol for 2.5 min. particle size 0.8 micron produced in a nebulizer connected to O2. After that gamma scintillation camera and computer were used for data acquiring in dynamic mode. After that ventilation and perfusion scintigraphy of the lungs was performed in four standard projections. Data processing was conducted with ROI drawing after both lungs on the added image. Clearance value was expressed in T1/2 (min), while the curves had monoexponential shape in all patients. In the non-smoking group mean clearance value for both lungs in patients suffering from PE, COPD and PN did not differ from NF. Clearance in the part of the lungs affected with disease (pneumonia, embolism) was faster than in healthy pulmonary tissue. In sick smokers, however, mean pulmonary clearance value was higher than in non-smokers, irrespective of the type of disease. Pulmonary clearance in individuals suffering from occupational diseases was also accelerated, irrespective of the fact whether the patients smoked or not.
测量吸入的99mTc - DTPA气雾剂放射性活度的下降速率可检测肺泡毛细血管膜完整性的紊乱。该研究纳入了21例患有不同肺部疾病（肺栓塞 - PE；慢性阻塞性肺疾病 - COPD；肺炎 - PN；职业病 - OD）的患者（11名非吸烟者和10名吸烟者），以检测肺上皮通透性（PEP）的紊乱情况，以及2名健康个体（非吸烟者），其检查结果正常（NF）。使用标准程序将1480 MBq的99mTc标记于1 ml生理盐水中的DTPA。鼻塞患者吸入气雾剂2.5分钟。通过连接到氧气的雾化器产生粒径为0.8微米的颗粒。之后，使用γ闪烁相机和计算机以动态模式采集数据。之后在四个标准投照下进行肺部通气和灌注闪烁显像。在叠加图像上对双肺进行感兴趣区（ROI）绘制后进行数据处理。清除值以T1/2（分钟）表示，所有患者的曲线均呈单指数形状。在非吸烟组中，患有PE、COPD和PN的患者双肺的平均清除值与NF组无差异。患病部位（肺炎、栓塞）的肺部清除速度比健康肺组织快。然而，在患病吸烟者中，无论疾病类型如何，平均肺清除值均高于非吸烟者。患有职业病的个体的肺部清除也加快，无论患者是否吸烟。
