非甾体抗炎药对肾小球肾炎患者肾血浆流量和肾小球滤过率的影响。
Effects of nonsteroidal antiinflammatory drugs on renal plasma flow and glomerular filtration rate in patients with glomerulonephritis.
作者信息
Stosić Z, Sedlak V, Curić S, Fellé D, Budakov P, Tepavcević P
机构信息
Department of Nephrology and Clinical Immunology, Faculty of Medicine, Novi Sad.
出版信息
Med Pregl. 1993;46 Suppl 1:36-7.
We investigated the effects of NSAIDs (Ibuprofen) on renal plasma flow (RPF) and glomerular filtration rate (GFR) in patients with glomerulonephritis. The study included 98 patients (53 men and 45 women) with idiopathic glomerulonephritis. All of the patients received Ibuprofen 1200 mg (3x400) during 7 days. Before and after the treatment with Ibuprofen ERPF (clearance of 131I-Hippuran) and GFR (clearance of 99mTc-DTPA) were determined. In our patients administration of Ibuprofen was associated with a significant reduction in renal plasma flow and glomerular filtration rate. In patients with reduced renal function the decrease in RPF and GFR after Ibuprofen was significantly greater than in patients with normal renal function.
我们研究了非甾体抗炎药（布洛芬）对肾小球肾炎患者肾血浆流量（RPF）和肾小球滤过率（GFR）的影响。该研究纳入了98例特发性肾小球肾炎患者（53例男性和45例女性）。所有患者在7天内服用布洛芬1200毫克（3×400）。在使用布洛芬治疗前后，测定有效肾血浆流量（131I-马尿酸清除率）和肾小球滤过率（99mTc-DTPA清除率）。在我们的患者中，服用布洛芬与肾血浆流量和肾小球滤过率显著降低有关。在肾功能减退的患者中，布洛芬治疗后肾血浆流量和肾小球滤过率的下降明显大于肾功能正常的患者。
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