Stajic S, Novaković R, Kostić N, Josifovski J, Simić P, Katić V, Kovijanić M
Institut of Nuclear Medicine, University Clinical Centre, Belgrade.
Med Pregl. 1993;46 Suppl 1:69-71.
Are the increased values of specific tumor markers significant in monitoring colorectal adenomas at the beginning of malignant alteration? Tumor markers (CEA, CA 19-9 and CA 72-4) were determined in sera by IRMA kits. The increased levels of tumor markers CEA and CA 19-9 were statistically very significant in patients (28) with colorectal adenomas at the beginning of malignant alteration and in the group with colorectal adenocarcinomas (96). By ROC analysis the sensitivities, positive predictive values and negative predictive values of CEA and CA 19-9 were quite acceptable with high accuracies for all determined tumor markers in colorectal adenomas at the beginning of malignant alteration. Those findings suggest the importance of monitoring of colorectal tumours and precancerouses by tumor markers serum levels and it confirms the usefulness of counting results by ROC analysis.
在恶性改变开始时，特定肿瘤标志物的升高值对监测大肠腺瘤是否具有重要意义？采用免疫放射分析试剂盒测定血清中的肿瘤标志物（癌胚抗原、CA 19-9和CA 72-4）。在处于恶性改变初期的大肠腺瘤患者（28例）以及大肠腺癌组（96例）中，肿瘤标志物癌胚抗原和CA 19-9水平升高具有统计学意义。通过ROC分析，对于处于恶性改变初期的大肠腺瘤中所有测定的肿瘤标志物，癌胚抗原和CA 19-9的敏感性、阳性预测值和阴性预测值相当可观，准确性较高。这些发现表明通过肿瘤标志物血清水平监测大肠肿瘤和癌前病变的重要性，并证实了通过ROC分析计算结果的有用性。
