Katsifis S P, Kinney P L, Hosselet S, Burns F J, Christie N T
Institute of Environmental Medicine, New York University Medical Center, NY 10016, USA.
Mutat Res. 1996 Jan 16;359(1):7-15. doi: 10.1016/s0165-1161(96)90004-7.
In this study, individual treatments of human lymphocytes with Ni(II) [0.5-25 microM], Cr(VI) [0.65-1.30 microM], UV-light or X-rays induced SCEs in a dose-dependent fashion, and combined treatments of Ni(II) with Cr(VI), UV-light or X-rays interacted antagonistically. Nickel, at environmentally relevant exposure levels, can have the effect in complex mixtures of reducing an otherwise positive SCE response and could lead to underestimating human exposures to certain classes of chemicals or radiation. Furthermore, our data indicate that antagonism may occur when human lymphocytes are exposed simultaneously to Ni(II) and Cr(VI), suggesting an explanation for epidemiological studies reporting conflicting results for cytogenetic effects in lymphocytes of workers exposed to chromium and nickel.
在本研究中，用镍（II）[0.5 - 25微摩尔]、铬（VI）[0.65 - 1.30微摩尔]、紫外线或X射线单独处理人淋巴细胞会以剂量依赖方式诱导姐妹染色单体交换（SCE），而镍（II）与铬（VI）、紫外线或X射线的联合处理具有拮抗作用。在与环境相关的暴露水平下，镍在复杂混合物中可产生降低原本阳性SCE反应的效果，这可能导致低估人类对某些种类化学物质或辐射的暴露。此外，我们的数据表明，当人淋巴细胞同时暴露于镍（II）和铬（VI）时可能会出现拮抗作用，这为流行病学研究中关于接触铬和镍的工人淋巴细胞细胞遗传学效应报告结果相互矛盾提供了解释。
