Smeets J W, Kunst M W
Rode Kruis Ziekenhuis, afd. Interne Geneeskunde, Beverwijk.
Ned Tijdschr Geneeskd. 1995 Dec 23;139(51):2667-9.
A 22-year-old man was admitted to hospital with severe, accidental intoxication with 4-aminopyridine, a medicine which increases the acetylcholine concentration in the synapses and has a limited application in the treatment of some neurological diseases. The patient acted on the assumption of body-building capacities of this 'amino'. Apart from the previously documented symptoms of intoxication such as an epileptic attack and confusion, he showed cardiac arrhythmias, conduction disorders and severe hypertension. The serum concentration of 4-aminopyridine was 335 mg/l, while the therapeutic level is 25-75 mg/l.
一名22岁男子因意外严重过量服用4-氨基吡啶入院。4-氨基吡啶是一种能增加突触中乙酰胆碱浓度的药物,在某些神经系统疾病的治疗中应用有限。该患者是基于认为这种“氨基”有增强体质能力的想法而服用的。除了先前记录的中毒症状,如癫痫发作和意识模糊外,他还出现了心律失常、传导障碍和严重高血压。4-氨基吡啶的血清浓度为335毫克/升,而治疗浓度为25 - 75毫克/升。