组胺对猫骨骼肌血管系统的影响。
The effects of histamine on skeletal muscle vasculature in cats.
作者信息
Flynn S B, Owen D A
出版信息
J Physiol. 1977 Mar;265(3):795-807. doi: 10.1113/jphysiol.1977.sp011744.
Abstract
- Experiments have been made to determine the vascular effects of histamine and the mechanism of histamine-induced oedema formation in cat skeletal muscle. 2. Histamine caused dose-dependent dilatation of resistance vessels and increased intravascular volume over the dose range 1 X 10(-10)-1 X 10(-8) mol/kg min. The dilatation of resistance vessels resulted in dose-dependent increases in capillary hydrostatic pressure. 3. Histamine increased vascular permeability, as measured by accumulation of [131I]human serum albumin in the tissue, during infusions at 1 X 10(-8) mol/kg min but no albumin accumulation could be detected at lower infusion rates. 4. Oedema formation during histamine infusion of 1 X 10(-10) and 1 X 10(-9) mol/kg min seemed to be due to increases in capillary hydrostatic pressure and independent of increased vascular permeability. During infusions of histamine 1 X 10(-8) mol/kg min oedema was due predominantly to increased vascular permeability and to a lesser extent, the increase in capillary hydrostatic pressure.
摘要
- 已开展实验以确定组胺对猫骨骼肌血管的影响以及组胺诱导水肿形成的机制。2. 在剂量范围为1×10⁻¹⁰ - 1×10⁻⁸ 摩尔/千克·分钟时，组胺导致阻力血管呈剂量依赖性扩张，并增加血管内容量。阻力血管的扩张导致毛细血管流体静压呈剂量依赖性增加。3. 以组织中[¹³¹I]人血清白蛋白的蓄积量衡量，在以1×10⁻⁸ 摩尔/千克·分钟的速率输注组胺时，组胺增加了血管通透性，但在较低输注速率下未检测到白蛋白蓄积。4. 在以1×10⁻¹⁰ 和1×10⁻⁹ 摩尔/千克·分钟的速率输注组胺期间，水肿形成似乎是由于毛细血管流体静压升高，且与血管通透性增加无关。在以1×10⁻⁸ 摩尔/千克·分钟的速率输注组胺期间，水肿主要是由于血管通透性增加，在较小程度上是由于毛细血管流体静压升高。
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