慢性丙型肝炎患者的基因型、丙型肝炎病毒核糖核酸血清水平及对α干扰素治疗的反应
Genotype, serum level of HCV-RNA and response to interferon-alpha treatment in patients with chronic hepatitis C.
作者信息
Clarysse C, Van den Eynde C, Nevens F, Portier C, Aelbrecht N, Fevery J, Yap S H
机构信息
Department of Liver and Pancreatic Disease, University Hospital Gasthuisberg, University of Leuven, Belgium.
出版信息
Neth J Med. 1995 Dec;47(6):265-71. doi: 10.1016/0300-2977(95)00101-8.
OBJECTIVE
Since only a small proportion of patients with chronic hepatitis C benefit from interferon therapy, we assessed the viral factors such as HCV genotype and the level of viraemia for prediction of interferon response.
METHODS
HCV genotype and serum levels of HCV-RNA were determined in 24 patients before, during and after interferon treatment.
RESULTS
Pre-treatment serum levels of HCV-RNA were significantly lower in patients with normalization of serum ALT and disappearance of serum HCV-RNA upon therapy than in patients with persistent abnormal ALT and/or serum HCV-RNA positivity. Sole infection with HCV genotype 1b was associated with a significantly higher pre-treatment serum HCV-RNA level than infection with genotype other than 1b or mixed types.
CONCLUSIONS
HCV genotype and pre-treatment serum HCV-RNA levels are indeed important predictors for response to interferon treatment in patients with chronic hepatitis C.
目的
由于仅有一小部分慢性丙型肝炎患者能从干扰素治疗中获益，我们评估了诸如丙肝病毒（HCV）基因型和病毒血症水平等病毒因素以预测干扰素治疗反应。
方法
在24例患者接受干扰素治疗前、治疗期间及治疗后测定HCV基因型和HCV-RNA血清水平。
结果
与血清谷丙转氨酶（ALT）持续异常和/或血清HCV-RNA阳性的患者相比，治疗后血清ALT恢复正常且血清HCV-RNA消失的患者，其治疗前血清HCV-RNA水平显著更低。单纯感染HCV 1b基因型患者的治疗前血清HCV-RNA水平显著高于感染非1b基因型或混合基因型的患者。
结论
HCV基因型和治疗前血清HCV-RNA水平确实是慢性丙型肝炎患者干扰素治疗反应的重要预测指标。
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