Katz-Salamon M, Jonsson B, Lagercrantz H
Neonatal Unit, Department of Woman and Child Health, Karolinska Hospital, Stockholm, Sweden.
Pediatr Pulmonol. 1995 Aug;20(2):101-6. doi: 10.1002/ppul.1950200209.
Infants with BPD often suffer from chronic hypoxia and require supplemental oxygen (O2). This might affect the sensitivity of peripheral chemoreceptors. Therefore, we assessed peripheral chemoreceptor function in 25 infants with bronchopulmonary dysplasia (BPD) of varying severity, using the hyperoxic test. These infants were compared with 35 preterm infants who did not develop BPD. All infants were tested during the 40th week of postconceptional age and their mean postnatal age was 81.5 +/- 16.3 days. Sixty percent (15/25) of the BPD infants lacked a hyperoxic response, while the proportion of nonresponders to O2 among the other groups was 20% (7/35). The intensity of this response was negatively correlated to time spent on a ventilator and positively to time without supplemental oxygen. The intensity of chemoreceptor function was closely related to the severity of BPD; none of the infants with the most severe form of BPD (grade 3) showed a ventilatory response to hyperoxia. Furthermore, infants with BPD needed significantly longer time to increase their saturation than did non-BPD infants (4.7 and 9.3 sec, respectively). We conclude that many infants with BPD, particularly those with the most severe form of the disease, have abnormally functioning peripheral chemoreceptors.
患有支气管肺发育不良（BPD）的婴儿常患有慢性缺氧，需要补充氧气（O2）。这可能会影响外周化学感受器的敏感性。因此，我们使用高氧试验评估了25名不同严重程度支气管肺发育不良（BPD）婴儿的外周化学感受器功能。将这些婴儿与35名未患BPD的早产儿进行比较。所有婴儿均在孕龄40周时接受测试，其平均出生后年龄为81.5±16.3天。60%（15/25）的BPD婴儿缺乏高氧反应，而其他组中对氧气无反应者的比例为20%（7/35）。这种反应的强度与使用呼吸机的时间呈负相关，与不补充氧气的时间呈正相关。化学感受器功能的强度与BPD的严重程度密切相关；最严重形式（3级）的BPD婴儿均未表现出对高氧的通气反应。此外，BPD婴儿比未患BPD的婴儿需要显著更长的时间来提高其血氧饱和度（分别为4.7秒和9.3秒）。我们得出结论，许多BPD婴儿，尤其是患有最严重形式疾病的婴儿，外周化学感受器功能异常。
