Yu V Y, Orgill A A, Lim S B, Bajuk B, Astbury J
Aust Paediatr J. 1983 Dec;19(4):233-6. doi: 10.1111/j.1440-1754.1983.tb02109.x.
Twenty-four (6%) of 375 infants with birthweights less than or equal to 1500g developed bronchopulmonary dysplasia (BPD); 16 (15%) of 107 in those less than or equal to 100g and 8 (3%) of 268 in those greater than 1000g. The incidence was 10% in those who required assisted ventilation. Perinatal asphyxia, significant respiratory distress, pulmonary interstitial emphysema and patent ductus arteriosus were statistically more common in BPD infants compared with the remaining 351 very low birthweight infants. Hyaline membrane disease was the primary respiratory disease in 54% of BPD infants. The mean durations of oxygen and ventilatory therapy were 68 days and 37 days respectively. Twenty-nine percent did not require more than 60% oxygen for over 24 hours. Only 38% required a peak airway pressure of over 30 cmH2O. Early postnatal growth was satisfactory on parenteral nutrition support. No perinatal factor was found to be predictive of death from BPD. The prolonged duration of hospital treatment has obvious implications to the psychosocial and economic costs of BPD.
375名出生体重小于或等于1500克的婴儿中，有24名（6%）患支气管肺发育不良（BPD）；体重小于或等于1000克的107名婴儿中有16名（15%）患病，体重大于1000克的268名婴儿中有8名（3%）患病。需要辅助通气的婴儿中，发病率为10%。与其余351名极低出生体重婴儿相比，围产期窒息、严重呼吸窘迫、肺间质气肿和动脉导管未闭在BPD婴儿中在统计学上更为常见。54%的BPD婴儿的原发性呼吸道疾病为透明膜病。氧气和通气治疗的平均持续时间分别为68天和37天。29%的婴儿在超过24小时的时间里不需要超过60%的氧气。只有38%的婴儿需要超过30厘米水柱的气道峰压。在肠外营养支持下，出生后早期生长情况令人满意。未发现围产期因素可预测BPD导致的死亡。住院治疗时间延长对BPD的心理社会和经济成本有明显影响。
