[氟西汀导致的三环类药物中毒血浆水平]
[Toxic tricyclic drug plasma level caused by fluoxetine].
作者信息
Hambrecht M
机构信息
Psychiatrische Klinik Zentralinstitut für Seelische Gesundheit, Mannheim.
出版信息
Psychiatr Prax. 1995 Nov;22(6):252-3.
PMID:8570758
Abstract
A case study illustrates that even after discontinuation fluoxetine still increases amtitriptyline plasma-levels. This is caused by an inhibition of the metabolism of tricyclics by fluoxetine which was still active due to the long elimination half-life of this substance and its metabolite.
摘要
一项案例研究表明，即使停用氟西汀后，其仍会提高阿米替林的血浆水平。这是由于氟西汀抑制三环类药物的代谢所致，由于该物质及其代谢物的消除半衰期较长，氟西汀仍具有活性。
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