Sammons L S, Kenyon R H, Hickman R L, Pedersen C E
Lab Anim Sci. 1977 Apr;27(2):229-34.
An attempt was made to find a suitable animal model for studies of spotted fever group rickettsiae. Inbred and outbred mice, the guinea pig, ferret, gerbil, hamster, wild rabbit, cotton rat, sheep, and miniature swine were tested. Of these, only certain strains of the mouse [Mai:(S) and BALB/cJ] and the guinea pig [Hla:(HA)] exhibited, overtly, the desired characteristics of disease. Other laboratory animals (such as sheep or rabbits) can be used for the production of antiserum against the spotted fever group of rickettsiae; however, these rickettsiae apparently have little or no effect on several other animal species. The lack of overt disease might explain the role of these animals or related genera as reservoirs for the tick-borne spotted fever rickettsiae.
人们试图寻找一种适合用于研究斑点热群立克次体的动物模型。对近交系和远交系小鼠、豚鼠、雪貂、沙鼠、仓鼠、野兔、棉鼠、绵羊和小型猪进行了测试。其中，只有某些品系的小鼠[Mai:(S)和BALB/cJ]以及豚鼠[Hla:(HA)]明显表现出所需的疾病特征。其他实验动物（如绵羊或兔子）可用于生产抗斑点热群立克次体的抗血清；然而，这些立克次体显然对其他几种动物物种几乎没有影响。缺乏明显疾病可能解释了这些动物或相关属作为蜱传斑点热立克次体储存宿主的作用。
