Campos U W, Holm D, Pachmann A, Vetter W
Departement für Innere Medizin, Universitä5sspital Zürich.
Praxis (Bern 1994). 1995 Dec 19;84(51-52):1522-8.
In this report, investigations on circadian blood pressure fluctuations in geriatric patients with or without senile dementia are reported. 24 patients of a nursing home in Zurich have been included in the study. In senile patients without dementia, persistence of circadian blood pressure rhythm, including a nocturnal decrease of blood pressure, could be demonstrated. In very old patients, however, reduced day-night amplitudes or loss of day-night rhythm, respectively, were observed. In the group of demented patients and in a subgroup including only patients with Alzheimer's disease, loss of circadian blood pressure rhythm and a lacking drop of nocturnal blood pressure values were found, while diurnal rhythmicity of the heart rate remained unchanged. Furthermore, our results demonstrate that there was no circadian blood pressure rhythm detectable in the five patients with Parkinson's syndrome (with or without dementia). The results of this study suggest that degenerative processes of the central nervous system interfere with circadian blood pressure rhythm.
在本报告中，报道了对患有或未患老年痴呆症的老年患者昼夜血压波动的研究。苏黎世一家养老院的24名患者被纳入该研究。在无痴呆症的老年患者中，可以证明昼夜血压节律持续存在，包括夜间血压下降。然而，在非常年老的患者中，分别观察到昼夜幅度减小或昼夜节律丧失。在痴呆患者组以及仅包括阿尔茨海默病患者的亚组中，发现昼夜血压节律丧失且夜间血压值无下降，而心率的昼夜节律保持不变。此外，我们的结果表明，五名帕金森综合征患者（无论是否患有痴呆症）均未检测到昼夜血压节律。这项研究的结果表明，中枢神经系统的退行性过程会干扰昼夜血压节律。
