Gülmezoğlu E
Mikrobiyol Bul. 1977 Jan;11(1):129-46.
Drugs, when bound with proteins invivo, become immunogenic. The immunogenic response is usually unnoticed, but occasionally it may be the cause of reactions which induce tissue damages. The immunologic mechanisms which induce tissue damages are classified in four types: 1) anaphylactic, 2) cytolytic, reactions mediated by immune complex, 4) delayed type hypersensitivity reactions. Besides these reactions certain drugs induce autoantibodies which give lupus signs. In the diagnosis of drug-induced reactions the history after drug intake is considered important. The prophylaxis and treatment of these reactions are discussed briefly.
药物在体内与蛋白质结合后会具有免疫原性。免疫原性反应通常不被注意，但偶尔可能是导致组织损伤反应的原因。引起组织损伤的免疫机制分为四种类型：1）过敏反应，2）细胞溶解反应，3）免疫复合物介导的反应，4）迟发型超敏反应。除了这些反应外，某些药物还会诱导产生自身抗体，出现狼疮症状。在药物诱导反应的诊断中，用药后的病史被认为很重要。本文简要讨论了这些反应的预防和治疗。
