St Georgiev V, Carlson R P, Van Inwegen R G, Khandwala A
J Med Chem. 1979 Apr;22(4):348-52. doi: 10.1021/jm00190a003.
A series of 1-phenylisoquinolines and related compounds was prepared and tested for potential antiallergic activity. Several compounds of this series inhibited the antigen-induced wheal formation in rat passive cutaneous anaphylaxis (PCA) assay, a commonly used test for antiallergic activity. Many of these compounds also inhibited the antigen-induced histamine release from passively sensitized guinea pig lung slices. Furthermore, almost all of these derivatives inhibited the cyclic nucleotide phosphodiesterase, suggesting this as one of several possible mechanisms of action.
制备了一系列1-苯基异喹啉及其相关化合物，并测试了它们的潜在抗过敏活性。该系列中的几种化合物在大鼠被动皮肤过敏反应（PCA）试验中抑制了抗原诱导的风团形成，这是一种常用的抗过敏活性测试。这些化合物中的许多还抑制了抗原诱导的被动致敏豚鼠肺切片中组胺的释放。此外，几乎所有这些衍生物都抑制了环核苷酸磷酸二酯酶，表明这是几种可能的作用机制之一。
