Itoh Y, Yamada M, Suematsu N, Matsushita M, Otomo E
Department of Internal Medicine, Yokufukai Geriatric Hospital, Tokyo, Japan.
Stroke. 1996 Feb;27(2):216-8. doi: 10.1161/01.str.27.2.216.
The inheritance of the epsilon 4 allele of the apolipoprotein E gene (APOE) is associated with increased risk of developing dementia of the Alzheimer type (DAT). We have investigated whether the APOE genotype influences the severity of cerebral amyloid angiopathy (CAA) in elderly individuals with or without DAT.
From a consecutive autopsy series, we studied 88 patients (85.2 +/- 8.1 years) without degenerative disorders other than DAT. The percentages of amyloid-laden vessels in the occipital lobes were calculated and compared between APOE genotypes.
For epsilon 3/3 and epsilon 3/4 genotypes, there was a trend toward increased CAA in epsilon 3/4 individuals for non-DAT and conversely in epsilon 3/3 individuals for DAT patients, but these did not achieve significance.
The present study suggests that the epsilon 4 allele is not a strong risk factor for CAA in elderly people.
载脂蛋白E基因（APOE）的ε4等位基因的遗传与患阿尔茨海默型痴呆（DAT）风险的增加相关。我们研究了APOE基因型是否影响患有或未患有DAT的老年人脑淀粉样血管病（CAA）的严重程度。
从一个连续尸检系列中，我们研究了88例患者（85.2±8.1岁），这些患者除DAT外无其他退行性疾病。计算枕叶中淀粉样蛋白沉积血管的百分比，并在不同APOE基因型之间进行比较。
对于ε3/3和ε3/4基因型，在非DAT患者中，ε3/4个体的CAA有增加趋势，而在DAT患者中，ε3/3个体的CAA有相反趋势，但这些均未达到显著水平。
本研究表明，ε4等位基因不是老年人CAA的强风险因素。
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