Leenen F H, Galla S J, Geyskes G G, Murdaugh H V, Shapiro A P
Nephron. 1977;18(2):93-100. doi: 10.1159/000180782.
The influence of one hemodialysis session and of subsequent loading by 1.5-2 liters N saline on blood pressure, PRA and body fluid compartments was assessed in seven patients with chronic renal failure on maintenance hemodialysis. Dialysis caused only slight decreases in plasma volume, ECV and in TEBS. Lying mean blood pressure by 5-10 mm Hg and PRA increased by 30%. Saline loading resulted in a significant increase in plasma volume by 0.4 liters and in blood pressure by 10-5 mm Hg, but in a decrease in PRA by 40%. The changes in mean blood pressure correlated positively with the changes in plasma volume, and negatively with the changes in PRA. It is concluded that the renin-angiotensin system in patients on chronic hemodialysis still functions as one of the adjustment mechanisms for the circulatory homeostasis, when challenged by volume loss or volume and sodium loading.
对7例维持性血液透析的慢性肾衰竭患者，评估了一次血液透析及随后输入1.5 - 2升生理盐水对血压、肾素活性（PRA）和体液 compartments的影响。透析仅使血浆容量、细胞外液容量（ECV）和全身体液量（TEBS）略有下降。卧位平均血压下降5 - 10 mmHg，PRA升高30%。输入生理盐水导致血浆容量显著增加0.4升，血压升高10 - 5 mmHg，但PRA下降40%。平均血压的变化与血浆容量的变化呈正相关，与PRA的变化呈负相关。得出结论，当受到容量丢失或容量及钠负荷挑战时，慢性血液透析患者的肾素 - 血管紧张素系统仍作为循环稳态的调节机制之一发挥作用。
