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[无功能肾移植的管理]

[Management of non-functioning renal graft].

作者信息

Ballesteros J J, Guzmán A, Puig J M, Cortadellas R, Munne A

机构信息

Servicio de Urología y Unidad Quirúrgica de Trasplante Renal, Hospital Ntra, Barcelona.

出版信息

Actas Urol Esp. 1995 Jun;19(6):446-54.

PMID:8571804
Abstract

On a series of 315 consecutive Renal Transplants (RT), the authors analyze the effects from any situation capable of causing the graft's renal failure, whether accompanied or not of oligoanuria. To begin with, the exploratory approach promoted by the ¿non-functioning kidney¿ is established recognizing three typical stages depending on the time of appearance: early, medium-term and long-term. The breakthroughs obtained in the prevention of Acute Tabular Necrosis (A.T.N.) are verified through the use of the receptor's hyperhydration, as well as the good results in the treatment of rejection since the arrival of Cyclosporin and the recent introduction of OKT3. Chronic rejection, is, today, the major cause of our transplantectomies (TX), since our attitude towards the exeresis of all irreversibly non-functioning grafts is well known. Vascular thrombotic problems have a very high percentage of losses among affected kidneys. Little can be done once the problem arises. Prevention is the best weapon available and special attention should be paid to the meticulousness of bank surgery and the suitable final positioning of the organ in the fossa iliaca, having into account the highly close relationship between this problem and the pathological and iatrogenic anomalies displayed by the organs to be transplanted in their arterial tree. The excretory tract problems are repaired in 83% cases, but the rest may even result in the loss of the kidney. In these complications, early surgery is the best way to avoid subsequent amputation surgery.

摘要

在一系列连续的315例肾移植手术中,作者分析了任何能够导致移植肾肾功能衰竭的情况所产生的影响,无论是否伴有少尿。首先,确立了由“无功能肾”推动的探索性方法,根据出现时间识别三个典型阶段:早期、中期和长期。通过受体的过度水化,验证了在预防急性肾小管坏死(A.T.N.)方面取得的突破,以及自环孢素问世和最近引入OKT3以来在治疗排斥反应方面取得的良好效果。如今,慢性排斥是我们进行移植肾切除术(TX)的主要原因,因为我们对所有不可逆无功能移植物切除的态度是众所周知的。血管血栓形成问题在受影响的肾脏中导致的损失比例非常高。一旦问题出现,能做的很少。预防是可用的最佳武器,应特别注意肾移植手术的细致程度以及器官在髂窝的合适最终定位,要考虑到这个问题与待移植器官动脉树中显示的病理和医源性异常之间的高度密切关系。83%的泌尿道问题得到修复,但其余问题甚至可能导致肾脏丢失。在这些并发症中,早期手术是避免后续截肢手术的最佳方法。

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