Nygaard I E, Kreder K J, Lepic M M, Fountain K A, Rhomberg A T
Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, USA.
Am J Obstet Gynecol. 1996 Jan;174(1 Pt 1):120-5. doi: 10.1016/s0002-9378(96)70383-6.
Our purpose was (1) to evaluate the efficacy on an intent-to-treat basis of a 3-month course of pelvic floor muscle exercises as first-line therapy for urinary incontinence in consecutive women seen in a tertiary care center with stress, urge, and mixed urinary incontinence and (2) to evaluate whether a specially designed audiotape improves compliance and efficacy of the exercises.
A prospective randomized trial wa conducted with 71 women seen for treatment of urinary incontinence in two tertiary care center referral clinics (in the departments of gynecology and urology). The primary outcome measure was the number of incontinent episodes, as documented with a 3-day voiding diary. Statistical analysis included t tests and Wilcoxon signed-ranks test, as appropriate. A value of p < or = 0.05 was considered significant.
Forty-four percent of all enrollees had a > or = 50% improvement in the number of incontinent episodes per day. This increased to 56% of enrolles who completed the treatment course. For all enrollees the mean number of incontinent episodes per day decreased from 2.6 to 1.7 for genuine stress incontinence, from 3.5 to 2.3 for detrusor instability, and from 3.9 to 3.2 for mixed incontinence. For enrollees who completed the 3-month course the mean number of incontinent episodes per day decreased from 2.5 to 1.4 for genuine stress incontinence, from 2.8 to 0.5 for detrusor instability, and from 3.0 to 1.7 for mixed incontinence. Six months after completing the course of exercises approximately one third of all enrollees reported that they continued to note good or excellent improvement and desired no further treatment. There was no difference in outcome measures and no difference in compliance between the women who exercised with the aid of the audiotape and those who exercised according to our usual office routine (p > 0.05).
One third of all participants remained improved to the patient's satisfaction 6 months after completion of a risk-free, inexpensive, simply provided therapy. Our audiotape did not improve our success rate or decrease the dropout rate. In this study the exercises were equally effective for all three urodynamic diagnoses. Inexpensive methods that could be used by primary care providers to improve the success rate of this therapy merits further attention.
我们的目的是(1)在一家三级医疗中心,对连续就诊的患有压力性、急迫性和混合性尿失禁的女性患者,评估为期3个月的盆底肌肉锻炼作为尿失禁一线治疗方案在意向性治疗基础上的疗效;(2)评估一种专门设计的录音带是否能提高锻炼的依从性和疗效。
在两家三级医疗中心的转诊诊所(妇科和泌尿科)对71名因尿失禁前来治疗的女性进行了一项前瞻性随机试验。主要结局指标是根据3天排尿日记记录的失禁发作次数。统计分析在适当情况下包括t检验和Wilcoxon符号秩检验。p≤0.05的值被认为具有统计学意义。
所有入组者中44%的人每天失禁发作次数改善≥50%。完成治疗疗程的入组者中这一比例增至56%。对于所有入组者,真性压力性尿失禁患者每天失禁发作的平均次数从2.6次降至1.7次,逼尿肌不稳定患者从3.5次降至2.3次,混合性尿失禁患者从3.9次降至3.2次。对于完成3个月疗程的入组者,真性压力性尿失禁患者每天失禁发作的平均次数从2.5次降至1.4次,逼尿肌不稳定患者从2.8次降至0.5次,混合性尿失禁患者从3.0次降至1.7次。完成锻炼疗程6个月后,约三分之一的入组者报告称他们仍持续有良好或极佳的改善,且无需进一步治疗。在借助录音带锻炼的女性和按照我们常规门诊程序锻炼的女性之间,结局指标和依从性均无差异(p>0.05)。
在完成一项无风险、低成本、简单易行的治疗6个月后,三分之一的参与者仍保持改善状态,令患者满意。我们的录音带并未提高成功率或降低脱落率。在本研究中,锻炼对所有三种尿动力学诊断同样有效。初级保健提供者可采用的提高该治疗成功率的低成本方法值得进一步关注。