Frezza M, Pozzato G, Valente G, Gilotta S, Milani S, Nicolini R
Minerva Med. 1977 Apr 7;68(17):1105-14.
S-adenosyl-L-methionine (SAMe) is a physiological compound which plays an important role in numerous biological processes, such as transmethylations, transulphurations and aminopropylations. Starting from a study about the usefulness of the SAMe to normalize protein synthesis in old age, the drug was found to have an interesting action with respect to fibrinogen. Later research regarding a large number of patients, led us to discover after treatment for 40 days with 60 mg/die of SAMe, highly significant variations in fibrinogen values with constant normalization of this parameter, in both hypo- and hyper-fibrinogenemia. So far we don't know anything about the action of the drug on various metabolic stages of the fibrinogen; interestingly however our data exclude a rise in fibrinolysis.
S-腺苷-L-甲硫氨酸（SAMe）是一种生理化合物，在众多生物过程中发挥着重要作用，如转甲基作用、转硫作用和氨丙基化作用。从一项关于SAMe对老年蛋白质合成正常化作用的研究开始，发现该药物对纤维蛋白原有有趣的作用。后来针对大量患者的研究，使我们发现在用60毫克/日的SAMe治疗40天后，无论在低纤维蛋白原血症还是高纤维蛋白原血症中，纤维蛋白原值都有高度显著的变化，且该参数持续正常化。到目前为止，我们对该药物在纤维蛋白原不同代谢阶段的作用一无所知；然而有趣的是，我们的数据排除了纤维蛋白溶解增加的可能性。
