Ferdeghini M, Gadducci A, Prontera C, Annicchiarico C, Gagetti O, Bianchi M, Facchini V, Genazzani A R
Istituto di Medicina Nucleare, Università di Pisa, Italy.
Anticancer Res. 1995 Sep-Oct;15(5B):2255-60.
The serum levels of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) were retrospectively measured in serum samples drawn at diagnosis from 66 patients with epithelial ovarian cancer and 128 patients with benign ovarian masses. The preoperative serum ICAM-1 levels were higher in the former group (p < 0.0001), while serum E-Selectin concentrations were similar in the two groups (p = NS). Among patients with epithelial ovarian cancer, neither serum ICAM-1 nor E-selectin levels correlated with FIGO stage and with histologic type. The serum assay of ICAM-1 and E-Selectin seems to have limited value in the management of patients with epithelial ovarian cancer.
