Witt M
Institute of Human Genetics, Polish Academy of Sciences, Poznań.
Arch Immunol Ther Exp (Warsz). 1994;42(5-6):345-8.
Several methods of molecular sexing (i.e. detection of Y-chromosomal sequences) have been briefly presented. In addition to other applications they can be used for monitoring of patients after sex-mismatched bone marrow transplantation for mixed chimerism and for detection of fetal cells in maternal circulation. Clinical significance of mixed chimerism and possibilities of non-invasive prenatal diagnosis with the use of fetal cells isolated from peripheral blood of pregnant women has been described.
本文简要介绍了几种分子性别鉴定方法（即检测Y染色体序列）。除其他应用外，它们可用于监测性别不匹配的骨髓移植后患者的混合嵌合体情况，以及检测母体循环中的胎儿细胞。文中还描述了混合嵌合体的临床意义以及利用从孕妇外周血中分离出的胎儿细胞进行无创产前诊断的可能性。
