Cooper G J, Abe Y, Miyama M, Deleuze P, Loisance D Y
Centre de Recherches Chirurgicales Henri Mondor, Association Claude Bernard, Créteil, France.
Artif Organs. 1995 Jul;19(7):739-41. doi: 10.1111/j.1525-1594.1995.tb02415.x.
We investigated the ability of the Hemopump to support the right ventricle during acute, partial, pulmonary artery obstruction. In 6 pigs, a 14 Fr size Hemopump was placed through the pulmonary artery into the right ventricle. Control measurements were made. A band around the pulmonary artery proximal to the outflow port of the Hemopump was tightened, and measurements were repeated with the Hemopump at minimum and then maximum speed. With banding, right ventricular stroke volume and output decreased (43 [SD, 7] to 28 [SD, 8] ml, p < 0.001; 4.9 [SD, 0.8] to 3.7 [SD, 1.0] L/min, p < 0.01 respectively), but they were restored with the Hemopump (38 [SD, 5] ml and 4.5 [SD, 0.6] L/min; both p = NS vs control). Increases in right ventricular peak systolic (28 [SD, 10] to 42 [SD, 17] mm Hg; p < 0.01) and end-diastolic pressure (2 [SD, 1] to 12 [SD, 6] mm Hg; p < 0.02) were reversed by the Hemopump (29 [SD, 8] and 4 [SD, 2] mm Hg; both p = NS vs control). Right ventricular pressure rate product almost doubled with banding (3,199 [SD, 1,252] to 5,962 [SD, 2,796] mm Hg; p < 0.01), but it decreased with the Hemopump (3,368 [SD, 767] mm Hg; p = NS vs control). With acute partial pulmonary artery banding, a right ventricular Hemopump restores output from and offloads the right ventricle.
我们研究了Hemopump在急性、部分性肺动脉阻塞期间支持右心室的能力。在6头猪中，将一个14 Fr尺寸的Hemopump经肺动脉置入右心室。进行对照测量。在Hemopump流出端口近端的肺动脉周围扎上一条束带，然后以Hemopump的最低速度和最高速度重复测量。扎带后，右心室每搏输出量和输出量下降（分别从43[标准差，7]降至28[标准差，8]ml，p<0.001；从4.9[标准差，0.8]降至3.7[标准差，1.0]L/min，p<0.01），但使用Hemopump后恢复（分别为38[标准差，5]ml和4.5[标准差，0.6]L/min；与对照相比，p均=无显著性差异）。右心室收缩期峰值（从28[标准差，10]升至42[标准差，17]mmHg；p<0.01）和舒张末期压力（从2[标准差，1]升至12[标准差，6]mmHg；p<0.02）的升高被Hemopump逆转（分别为29[标准差，8]和4[标准差，2]mmHg；与对照相比，p均=无显著性差异）。扎带后右心室压力速率乘积几乎翻倍（从3199[标准差，1252]升至5962[标准差，2796]mmHg；p<0.01），但使用Hemopump后下降（3368[标准差，767]mmHg；与对照相比，p=无显著性差异）。在急性部分性肺动脉扎带时，右心室Hemopump可恢复右心室的输出并减轻其负荷。
