Allison J P, Hurwitz A A, Leach D R
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
Curr Opin Immunol. 1995 Oct;7(5):682-6. doi: 10.1016/0952-7915(95)80077-8.
One of the major goals of tumor immunotherapy is the induction of tumor-specific T-cell responses that will be effective in eradicating disseminated tumors. Emerging information on the role of costimulatory molecules in T-cell activation offers several new strategies for enhancing antitumor responses, including the induction of expression of costimulatory molecules on tumor cells, enhancement of the presentation of transferred tumor antigen by host antigen-presenting cells, and ex vivo antigen priming of autologous antigen-presenting cells.
肿瘤免疫疗法的主要目标之一是诱导肿瘤特异性T细胞反应，这种反应将有效地根除播散性肿瘤。关于共刺激分子在T细胞活化中的作用的新信息提供了几种增强抗肿瘤反应的新策略，包括诱导肿瘤细胞上共刺激分子的表达、增强宿主抗原呈递细胞对转移肿瘤抗原的呈递，以及对自体抗原呈递细胞进行体外抗原致敏。
