Wassarman P M
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110-1199, USA.
Curr Opin Cell Biol. 1995 Oct;7(5):658-64. doi: 10.1016/0955-0674(95)80107-3.
The process of fertilization is fundamental to the maintenance of life. The ability of unfertilized eggs and free-swimming sperm to recognize, adhere to, and fuse with each other are vital aspects of the fertilization process. Significant progress has been made recently in identifying and characterizing (glyco)proteins that are associated with the surface of mammalian gametes and that support adhesion and fusion of eggs and sperm. As a result, there are currently reasons to believe that, in mammals, species-specific gamete adhesion is carbohydrate-mediated and gamete fusion is intergrin-mediated.
受精过程是维持生命的基础。未受精的卵子和自由游动的精子相互识别、黏附并融合的能力是受精过程的关键方面。最近在鉴定和表征与哺乳动物配子表面相关且支持卵子和精子黏附与融合的（糖）蛋白方面取得了重大进展。因此，目前有理由相信，在哺乳动物中，物种特异性的配子黏附是由碳水化合物介导的，而配子融合是由整合素介导的。
