Analysis of sulfamethazine in the presence of sulfamerazine or sulfadiazine by first-derivative photochemically induced fluorescence.

作者信息

Sanchez Pena M, Acedo M J, Salinas F, Mahedero M C, Aaron J J

机构信息

Department of Analytical Chemistry, Faculty of Sciences, University of Extramadura, Badajoz, Spain.

出版信息

J Pharm Biomed Anal. 1995 Aug;13(9):1107-12. doi: 10.1016/0731-7085(95)01555-y.

A first-derivative photochemically-induced fluorescence method is proposed for the determination of sulfamethazine (SMTZ) in the presence of sulfamerazine (SMRZ) or sulfadiazine (SDZ). Linear calibration plots were obtained for SMTZ in SMTZ-SMRZ or SMTZ-SDZ binary mixtures with correlation coefficients larger than 0.999. For SMTZ the lower limits of detection were 7-13 ppb. Recoveries of 91-114% were obtained in the analysis of SMTZ in pharmaceutical formulations.